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Translational Research: Canine osteosarcoma as a model in comparative oncology

A recent study published in Nature explores how the study of cancer in dogs can advance our understanding and treatment of human cancer.


𝐂𝐨𝐦𝐩𝐚𝐫𝐚𝐭𝐢𝐯𝐞 𝐎𝐧𝐜𝐨𝐥𝐨𝐠𝐲

Dogs with osteosarcoma share many biological and molecular parallels with humans. This similarity makes dogs invaluable models for studying the disease's complex nature and potential treatments.


𝐃𝐚𝐭𝐚-𝐃𝐫𝐢𝐯𝐞𝐧 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬

The study leveraged a large cohort of canine osteosarcoma samples from a clinical trial, providing standardized diagnostic and therapeutic data. 


𝐓𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐑𝐞𝐥𝐞𝐯𝐚𝐧𝐜𝐞

These resources facilitated the identification of distinct patient subgroups and gene signatures, which can be translatable to human osteosarcoma research and treatment.


𝐃𝐫𝐮𝐠 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭

A collaborative synergy between the veterinary and human medical fields can accelerate the development of novel drugs, benefiting both animal and human patients.


𝐎𝐧𝐞 𝐡𝐞𝐚𝐥𝐭𝐡

▶ Many diseases and conditions impact both animals and humans. 


▶ Embracing an interdisciplinary approach holds great promise for advancing our comprehension of diseases, expanding treatment options, and enhancing the well-being of both animals and humans.


About the author  

Dr. Aline Santana is a Brazilian veterinarian with over 12 years of experience in both research and private dermatology practice. In 2021, she completed her PhD in veterinary dermatology at the University of São Paulo (Brazil), with a sandwich period at the University of Minnesota, where she conducted research on the skin microbiome of cats. Since 2012, she has been an active member of the Brazilian Society of Veterinary Dermatology (SBDV). From 2015 to 2021, Dr. Santana served as the director of social media marketing, contributing to the organization's outreach and communication efforts.

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