Gut Microbiota Changes in Dogs with Atopic Dermatitis
A recent study has shown significant changes in the gut microbiota of dogs with atopic dermatitis (AD). The atopic dogs had a significantly lower gut microbiota diversity when compared to healthy dogs. Moreover, allergic dogs showed a significantly reduced abundance of bacteria belonging to the family Lachnospiraceae, which seems to be involved in gut epithelial barrier integrity and #immune regulation.
Gut dysbiosis
These results suggest that the gut microbiota may play an important role in the pathogenesis of canine AD. Gut dysbiosis can increase the production of pro-inflammatory cytokines and promote an increased intestinal permeability, enabling the penetration of intestinal toxins and propelling skin inflammation.
Multiomics
🎯 Future #multiomics studies have the potential to identify biomarkers for the purposes of diagnostics and therapeutic monitoring.
📖 References:
➡️ Rostaher et al. Comparison of the Gut Microbiome between Atopic and Healthy Dogs: Preliminary Data. Animals, 2022
➡️ Marsella R. Advances in our understanding of canine atopic Dermatitis. Vet Dermatology, 2021
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